modelCombinations
Extends from Pharmacolibrary.Drugs.ATC.A.A01AA30.
Information
| name: | Combinations | |
| ATC code: | A01AA30 | route: | topical |
| compartments: | 1 | |
| dosage: | 20 | mg |
| volume of distribution: | 50 | L |
| clearance: | 48 | L/h |
| other parameters in model implementation | ||
ATC code A01AA30 covers combinations of tetracycline antibiotics for dental use. These formulations are typically used topically in the oral cavity to manage gingivitis, periodontitis, and other oral infections. Such combinations may be rarely used today, and have largely been replaced by more targeted or systemic therapies in clinical practice.
Pharmacokinetics
No published pharmacokinetic model parameters are available for tetracycline combinations formulated for dental topical use in humans. Estimates here are deduced from single-component topical tetracycline oral gel studies in adults.
References
Petersson, LG (1993). Fluoride mouthrinses and fluoride varnishes. Caries research 27 Suppl 1 35–42. DOI:10.1159/000261600 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8500123
Tran, AN, & Koo, JY (2014). Risk of systemic toxicity with topical lidocaine/prilocaine: a review. Journal of drugs in dermatology : JDD 13(9) 1118–1122. PUBMED:https://pubmed.ncbi.nlm.nih.gov/25226014
Li, L, et al., & Ma, P (2023). Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers. BMC pharmacology & toxicology 24(1) 51–None. DOI:10.1186/s40360-023-00690-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/37828535
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)