modelSodiumFluorideCombinatio
Extends from Pharmacolibrary.Drugs.ATC.A.A01AA51.
Information
| name: | SodiumFluorideCombinations | |
| ATC code: | A01AA51 | route: | oral |
| compartments: | 1 | |
| dosage: | 2 | mg |
| volume of distribution: | 0.6 | L |
| clearance: | 0.12 | L/kg/h |
| other parameters in model implementation | ||
Sodium fluoride, in combination with other agents, is typically used topically or systemically for the prevention of dental caries through the promotion of remineralization of tooth enamel. Its systemic use is less common nowadays, and its main indication is dental hygiene and prevention of cavities. It is generally regarded as safe when used as indicated, but systemic application is not routinely recommended for general populations in most countries today.
Pharmacokinetics
Estimated typical pharmacokinetics in healthy adults, based on available data for sodium fluoride; no direct studies found for combinations under ATC code A01AA51.
References
Lin, YS, et al., & Milgrom, P (2018). Pharmacokinetics of Iodine and Fluoride following Application of an Anticaries Varnish in Adults. JDR clinical and translational research 3(3) 238–245. DOI:10.1177/2380084418771930 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30938600
Ivanoff, CS, et al., & Garcia-Godoy, F (2013). Enhanced penetration of fluoride particles into bovine enamel by combining dielectrophoresis with AC electroosmosis. Electrophoresis 34(20-21) 2945–2955. DOI:10.1002/elps.201300206 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23897721
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)