modelTriamcinolone
Extends from Pharmacolibrary.Drugs.ATC.A.A01AC01.
Information
| name: | Triamcinolone | |
| ATC code: | A01AC01 | route: | topical |
| compartments: | 1 | |
| dosage: | 5 | mg |
| volume of distribution: | 97.5 | L |
| clearance: | 11.2 | L/h |
| other parameters in model implementation | ||
Triamcinolone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, used to treat a range of conditions such as oral inflammatory diseases (as a dental paste), dermatological disorders, and allergic reactions. It is approved and currently used in various formulations including topical, oral, inhalational, and injectable forms.
Pharmacokinetics
Pharmacokinetic parameters estimated for healthy adults for oral topical (dental paste/buccal) administration; literature reporting specific parameters for the dental paste or topical oral form is lacking. Estimates are extrapolated from systemic use and closely related topical or oral administration data.
References
Ramadas, AA, et al., & Kumar, SP (2016). Systemic absorption of 0.1% triamcinolone acetonide as topical application in management of oral lichen planus. Indian journal of dental research : official publication of Indian Society for Dental Research 27(3) 230–235. DOI:10.4103/0970-9290.186237 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27411649
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)