modelPrednisone
Extends from Pharmacolibrary.Drugs.ATC.A.A07EA03.
Information
| name: | Prednisone | |
| ATC code: | A07EA03 | route: | oral |
| compartments: | 1 | |
| dosage: | 20 | mg |
| volume of distribution: | 0.4 | L |
| clearance: | 0.12 | L/hr/kg |
| other parameters in model implementation | ||
Prednisone is a synthetic glucocorticoid drug commonly used as an anti-inflammatory and immunosuppressant in the treatment of conditions such as asthma, rheumatoid arthritis, allergic disorders, and autoimmune diseases. It is an oral prodrug, metabolized in the liver to its active form, prednisolone. Prednisone is widely approved and used in clinical practice today.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers after oral administration.
References
de Truchis, C, et al., & Boyer, O (2023). Prednisolone pharmacokinetics after oral prednisone administration in paediatric patients with kidney transplant. British journal of clinical pharmacology 89(5) 1532–1540. DOI:10.1111/bcp.15610 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36510685
Romano-Aguilar, M, et al., & Romano-Moreno, S (2020). Population pharmacokinetics of mycophenolic acid in Mexican patients with lupus nephritis. Lupus 29(9) 1067–1077. DOI:10.1177/0961203320931567 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32539658
Velickovic-Radovanovic, R, et al., & Jankovic, SM (2010). Population pharmacokinetics of tacrolimus in kidney transplant patients. International journal of clinical pharmacology and therapeutics 48(6) 375–382. DOI:10.5414/cpp48375 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20497746
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)