modelSodiumChloride
Extends from Pharmacolibrary.Drugs.ATC.A.A12CA01.
Information
| name: | SodiumChloride | |
| ATC code: | A12CA01 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 9000 | mg |
| volume of distribution: | 14 | L |
| clearance: | 6 | L/h |
| other parameters in model implementation | ||
Sodium chloride is an essential electrolyte that is widely used in medicine as an isotonic solution for fluid and electrolyte replenishment, intravenous hydration, and as a vehicle for the administration of parenteral drugs. It is approved and routinely used in clinical practice.
Pharmacokinetics
Pharmacokinetic parameters are not routinely measured for sodium chloride as a therapeutic agent, because it is an endogenous substance with rapid distribution and elimination dependent on homeostatic renal mechanisms. The following estimates are provided for a typical healthy adult after intravenous administration.
References
Parker, SL, et al., & Roberts, JA (2018). Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury. Journal of critical care 47 15–20. DOI:10.1016/j.jcrc.2018.05.016 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29883885
Liu, Y, et al., & Wang, X (2023). Pharmacokinetics and safety of injected ornidazole compared to its enantiomer levornidazole in healthy Chinese subjects. International journal of clinical pharmacology and therapeutics 61(12) 543–550. DOI:10.5414/CP204442 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37840522
Levitskaia, TG, et al., & Thrall, KD (2010). Biomaterials for the decorporation of (85)Sr in the rat. Health physics 99(3) 394–400. DOI:10.1097/HP.0b013e3181c4717d PUBMED:https://pubmed.ncbi.nlm.nih.gov/20699703
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)