modelGlutamine
Extends from Pharmacolibrary.Drugs.ATC.A.A16AA03.
Information
| name: | Glutamine | |
| ATC code: | A16AA03 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 30000 | mg |
| volume of distribution: | 17 | L |
| clearance: | 8 | L/h |
| other parameters in model implementation | ||
Glutamine is an amino acid widely used as a nutritional supplement for support during severe illness, trauma, or gastrointestinal disorders. It is not considered an 'approved drug' under a specific indication, but glutamine supplementation is often used in parenteral nutrition, particularly in critically ill or surgical patients to support immune function and gut integrity.
Pharmacokinetics
Estimated pharmacokinetic parameters for healthy adults; published data on pharmacokinetics for exogenous glutamine are extremely limited.
References
Manzanares, W, et al., & Heyland, DK (2015). Pharmaconutrition with selenium in critically ill patients: what do we know?. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 30(1) 34–43. DOI:10.1177/0884533614561794 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25524883
Ziegler, TR, et al., & Wilmore, DW (1990). Safety and metabolic effects of L-glutamine administration in humans. JPEN. Journal of parenteral and enteral nutrition 14(4 Suppl) 137S–146S. DOI:10.1177/0148607190014004201 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2119459
Wang, X, et al., & Vilchez, RA (2021). Exposures of Phenylacetic Acid and Phenylacetylglutamine Across Different Subpopulations and Correlation with Adverse Events. Clinical pharmacokinetics 60(12) 1557–1567. DOI:10.1007/s40262-021-01047-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34125423
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)