modelBivalirudin
Extends from Pharmacolibrary.Drugs.ATC.B.B01AE06.
Information
| name: | Bivalirudin | |
| ATC code: | B01AE06 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 0.75 | mg |
| volume of distribution: | 0.2 | L |
| clearance: | 3.4 | mL/min/kg |
| other parameters in model implementation | ||
Bivalirudin is a synthetic 20-amino acid polypeptide direct thrombin inhibitor used as an anticoagulant, mainly in the setting of percutaneous coronary intervention (PCI), and approved for use as an alternative to heparin, particularly in patients with or at risk for heparin-induced thrombocytopenia. It is approved by the FDA and used in current clinical practice.
Pharmacokinetics
Pharmacokinetics in adult patients undergoing percutaneous coronary intervention, both male and female, normal renal and hepatic function.
References
Zhang, DM, et al., & Cui, YM (2012). Population pharmacokinetics and pharmacodynamics of bivalirudin in young healthy Chinese volunteers. Acta pharmacologica Sinica 33(11) 1387–1394. DOI:10.1038/aps.2012.37 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22659624
Zhang, D, et al., & Cui, Y (2011). Pharmacokinetics, pharmacodynamics, tolerability and safety of single doses of bivalirudin in healthy chinese subjects. Biological & pharmaceutical bulletin 34(12) 1841–1848. DOI:10.1248/bpb.34.1841 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22130240
Scandroglio, AM, et al., & Pappalardo, F (2021). Impact of CytoSorb on kinetics of vancomycin and bivalirudin in critically ill patients. Artificial organs 45(9) 1097–1103. DOI:10.1111/aor.13952 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33686696
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)