modelAminoAcids
Extends from Pharmacolibrary.Drugs.ATC.B.B05BA01.
Information
| name: | AminoAcids | |
| ATC code: | B05BA01 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 1000 | mg |
| volume of distribution: | 0.25 | L |
| clearance: | 1.2 | l/kg/h |
| other parameters in model implementation | ||
Amino acids solutions (ATC B05BA01) are sterile mixtures of naturally occurring amino acids intended for intravenous administration as part of parenteral nutrition to provide nutritional support to patients who are unable to obtain adequate nutrition orally or enterally. They are used in clinical settings such as intensive care, post-operative care, and for patients with impaired gastrointestinal function. They are approved and widely used in clinical practice.
Pharmacokinetics
Pharmacokinetics of intravenously administered standard amino acid solutions in adult healthy volunteers; typical infusion duration of several hours.
References
Keizer, RJ, et al., & Beijnen, JH (2010). Clinical pharmacokinetics of therapeutic monoclonal antibodies. Clinical pharmacokinetics 49(8) 493–507. DOI:10.2165/11531280-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20608753
Bier, DM (2003). Amino acid pharmacokinetics and safety assessment. The Journal of nutrition 133(6 Suppl 1) 2034S–2039S. DOI:10.1093/jn/133.6.2034S PUBMED:https://pubmed.ncbi.nlm.nih.gov/12771361
Riedl, M (2015). Recombinant human C1 esterase inhibitor in the management of hereditary angioedema. Clinical drug investigation 35(7) 407–417. DOI:10.1007/s40261-015-0300-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/26091744
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)