modelPotassiumChloride
Extends from Pharmacolibrary.Drugs.ATC.B.B05XA01.
Information
| name: | PotassiumChloride | |
| ATC code: | B05XA01 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 20 | mg |
| volume of distribution: | 0.5 | L |
| clearance: | 4.6 | L/h |
| other parameters in model implementation | ||
Potassium chloride is an electrolyte supplement used for the prevention and treatment of hypokalemia (low potassium levels). It is commonly administered orally or intravenously in clinical practice and is approved for use today.
Pharmacokinetics
Estimated pharmacokinetic parameters for healthy adults, as literature describing compartmental PK models for potassium chloride is lacking. Potassium is an endogenous ion with rapid distribution, so a 1-compartment model is assumed for intravenous administration.
References
Suh, A, et al., & Rosa, RM (2004). Racial differences in potassium disposal. Kidney international 66(3) 1076–1081. DOI:10.1111/j.1523-1755.2004.00857.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/15327401
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)