modelConestatAlfa
Extends from Pharmacolibrary.Drugs.ATC.B.B06AC04.
Information
| name: | ConestatAlfa | |
| ATC code: | B06AC04 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 2100 | mg |
| volume of distribution: | 3.0 | L |
| clearance: | 0.2 | L/h |
| other parameters in model implementation | ||
Conestat alfa is a recombinant human C1 esterase inhibitor (C1-INH) used for the treatment of acute angioedema attacks in patients with hereditary angioedema (HAE). It functions by replacing deficient or dysfunctional C1-INH in HAE patients to inhibit the complement system and control inflammation. Conestat alfa is approved for clinical use in Europe, but not in all countries worldwide.
Pharmacokinetics
Pharmacokinetic parameters are estimated for typical adult patients with hereditary angioedema based on available regulatory reviews and product information, as no peer-reviewed publication with primary PK study in humans is available.
References
Riedl, MA, et al., & Cicardi, M (2017). Recombinant human C1 esterase inhibitor for prophylaxis of hereditary angio-oedema: a phase 2, multicentre, randomised, double-blind, placebo-controlled crossover trial. Lancet (London, England) 390(10102) 1595–1602. DOI:10.1016/S0140-6736(17)31963-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28754491
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)