modelCenthaquine
Extends from Pharmacolibrary.Drugs.ATC.C.C01CA28.
Information
| name: | Centhaquine | |
| ATC code: | C01CA28 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 15 | L |
| clearance: | 22 | L/hour |
| other parameters in model implementation | ||
Centhaquine is a novel resuscitative agent developed for the treatment of hypovolemic shock. It acts as an alpha-adrenergic receptor agonist to increase venous return and improve cardiac output. Centhaquine has undergone phase 2 and phase 3 clinical trials for hypovolemic and hemorrhagic shock but is not widely approved or in routine clinical use globally.
Pharmacokinetics
No specific human pharmacokinetic studies or parameter values are published for centhaquine as of 2024. Estimates below are inferred from typical intravenous agent properties and available preclinical/clinical abstracts.
References
O'Donnell, JN, et al., & Scheetz, MH (2016). Pharmacokinetics of centhaquin citrate in a dog model. The Journal of pharmacy and pharmacology 68(6) 803–809. DOI:10.1111/jphp.12554 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27109141
O'Donnell, JN, et al., & Scheetz, MH (2016). Pharmacokinetics of centhaquin citrate in a rat model. The Journal of pharmacy and pharmacology 68(1) 56–62. DOI:10.1111/jphp.12498 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26725913
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)