modelMilrinone
Extends from Pharmacolibrary.Drugs.ATC.C.C01CE02.
Information
| name: | Milrinone | |
| ATC code: | C01CE02 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 50 | mg |
| volume of distribution: | 0.5 | L |
| clearance: | 0.13 | L/kg/h |
| other parameters in model implementation | ||
Milrinone is a phosphodiesterase 3 inhibitor used mainly for the short-term treatment of acute decompensated heart failure and for patients with severe heart failure unresponsive to conventional therapy. It produces positive inotropic and vasodilatory effects. Milrinone is approved and utilized in hospital settings, particularly in intensive care.
Pharmacokinetics
Pharmacokinetic parameters reported in adult patients with congestive heart failure after intravenous administration.
References
Hornik, CP, et al., & Gonzalez, D (2019). Population Pharmacokinetics of Milrinone in Infants, Children, and Adolescents. Journal of clinical pharmacology 59(12) 1606–1619. DOI:10.1002/jcph.1499 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31317556
Commander, SJ, et al., & Hornik, CP (2022). The relationship between simulated milrinone exposure and hypotension in children. Cardiology in the young 32(5) 782–788. DOI:10.1017/S1047951121003103 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34350821
Pellicer, A, et al., & Cabañas, F (2013). Phase 1 study of two inodilators in neonates undergoing cardiovascular surgery. Pediatric research 73(1) 95–103. DOI:10.1038/pr.2012.154 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23138399
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)