modelAdenosine
Extends from Pharmacolibrary.Drugs.ATC.C.C01EB10.
Information
| name: | Adenosine | |
| ATC code: | C01EB10 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 6 | mg |
| volume of distribution: | 0.21 | L |
| clearance: | 15 | L/min |
| other parameters in model implementation | ||
Adenosine is an endogenous purine nucleoside approved for the rapid conversion of paroxysmal supraventricular tachycardia (PSVT) to normal sinus rhythm. It acts on adenosine receptors to inhibit conduction through the atrioventricular node and is used primarily in acute cardiac care settings. Adenosine is approved and widely used today as an intravenous antiarrhythmic agent.
Pharmacokinetics
Pharmacokinetic model reported in healthy adult subjects; most data from intravenous administration due to extremely low oral bioavailability.
References
Motovska, Z, et al., & Group, DS (2024). Cangrelor versus crushed ticagrelor in patients with acute myocardial infarction and cardiogenic shock: rationale and design of the randomised, double-blind DAPT-SHOCK-AMI trial. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20(20) e1309–e1318. DOI:10.4244/EIJ-D-24-00203 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39432252
Bateman, RM, et al., & Prandi, E (2016). 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Critical care (London, England) 20(Suppl 2) 94–None. DOI:10.1186/s13054-016-1208-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27885969
Ahmed, A, et al., & Rojo, P (2024). Remdesivir for COVID-19 in Hospitalized Children: A Phase 2/3 Study. Pediatrics 153(3) –. DOI:10.1542/peds.2023-063775 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38332740
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)