modelMiconazoleCombinations
Extends from Pharmacolibrary.Drugs.ATC.D.D01AC52.
Information
| name: | MiconazoleCombinations | |
| ATC code: | D01AC52 | route: | topical |
| compartments: | 1 | |
| dosage: | 20 | mg |
| volume of distribution: | 1.5 | L |
| clearance: | 0.025 | L/h/kg |
| other parameters in model implementation | ||
Miconazole is an imidazole antifungal agent used primarily for the topical treatment of fungal infections such as dermatophytosis, cutaneous candidiasis, tinea, and pityriasis versicolor. Combinations (ATC D01AC52) refer to formulations where miconazole is combined with other active substances to broaden antifungal spectrum or treat associated symptoms. Miconazole in various combination forms is still approved today for topical use.
Pharmacokinetics
No published pharmacokinetic models or parameters were identified specifically for miconazole in combination (ATC D01AC52). Parameters below are rough estimates based on known PK of topical miconazole and other imidazoles in healthy adults.
References
Saunders, PP, et al., & Richards, JS (1992). Enhanced killing of Acanthamoeba cysts in vitro using dimethylsulfoxide. Ophthalmology 99(8) 1197–1200. DOI:10.1016/s0161-6420(92)31823-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1513571
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)