modelGentamicin
Extends from Pharmacolibrary.Drugs.ATC.D.D06AX07.
Information
| name: | Gentamicin | |
| ATC code: | D06AX07 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 80 | mg |
| volume of distribution: | 0.25 | L |
| clearance: | 90 | ml/min |
| other parameters in model implementation | ||
Gentamicin is an aminoglycoside antibiotic used primarily to treat various types of bacterial infections, especially those caused by Gram-negative organisms. It is commonly used for severe systemic infections such as sepsis, respiratory tract infections, urinary tract infections, and intra-abdominal infections. Gentamicin is still approved and in clinical use today, typically administered parenterally due to poor gastrointestinal absorption.
Pharmacokinetics
Pharmacokinetic parameters reported for adult healthy volunteers; intravenous administration.
References
Medellín-Garibay, SE, et al., & Barcia, E (2015). Population pharmacokinetics of gentamicin and dosing optimization for infants. Antimicrobial agents and chemotherapy 59(1) 482–489. DOI:10.1128/AAC.03464-14 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25385111
Boisson, M, et al., & Grégoire, N (2018). Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. The Journal of antimicrobial chemotherapy 73(10) 2830–2837. DOI:10.1093/jac/dky239 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947799
Lares-Asseff, I, et al., & Lugo Goytia, G (2016). Population Pharmacokinetics of Gentamicin in Mexican Children With Severe Malnutrition. The Pediatric infectious disease journal 35(8) 872–878. DOI:10.1097/INF.0000000000001204 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27420805
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)