modelHydrocortisoneAndAntisep
Extends from Pharmacolibrary.Drugs.ATC.D.D07BA04.
Information
| name: | HydrocortisoneAndAntiseptics | |
| ATC code: | D07BA04 | route: | topical |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 40 | L |
| clearance: | 16 | L/h |
| other parameters in model implementation | ||
Hydrocortisone and antiseptics is a topical combination medication typically used for the treatment of inflammatory skin disorders with a risk of or presence of secondary infection. Hydrocortisone is a corticosteroid with anti-inflammatory and immunosuppressive properties, while antiseptics such as chlorhexidine are included to reduce microbial colonization. This combination is primarily indicated in dermatology. Hydrocortisone and antiseptics combination is approved for topical use in several countries.
Pharmacokinetics
No published population or detailed pharmacokinetic models for the fixed combination of hydrocortisone and antiseptics (ATC D07BA04) are available; pharmacokinetic parameters are estimated based on published data for topical hydrocortisone use in adults with healthy or inflamed skin.
References
Mills, PC, et al., & Cross, SE (2005). Effects of vehicle and region of application on absorption of hydrocortisone through canine skin. American journal of veterinary research 66(1) 43–47. DOI:10.2460/ajvr.2005.66.43 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15691034
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)