modelTriamcinolone
Extends from Pharmacolibrary.Drugs.ATC.D.D07XB02.
Information
| name: | Triamcinolone | |
| ATC code: | D07XB02 | route: | topical |
| compartments: | 1 | |
| dosage: | 15 | mg |
| volume of distribution: | 58 | L |
| clearance: | 3.2 | L/h |
| other parameters in model implementation | ||
Triamcinolone is a synthetic corticosteroid used for its anti-inflammatory and immunosuppressive properties. It is approved and widely used today in topical, inhaled, injectable, and intranasal forms for the treatment of various conditions such as allergic disorders, skin diseases, arthritic conditions, and for asthma and hay fever.
Pharmacokinetics
Estimated typical pharmacokinetic parameters for adults following dermal (topical) application; specific PK values for topical administration are rarely published, and data reported here are best estimates based on published intravenous and oral formulations, and corticosteroid class.
References
Ramadas, AA, et al., & Kumar, SP (2016). Systemic absorption of 0.1% triamcinolone acetonide as topical application in management of oral lichen planus. Indian journal of dental research : official publication of Indian Society for Dental Research 27(3) 230–235. DOI:10.4103/0970-9290.186237 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27411649
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)