modelMercuricChloride
Extends from Pharmacolibrary.Drugs.ATC.D.D08AK03.
Information
| name: | MercuricChloride | |
| ATC code: | D08AK03 | route: | oral |
| compartments: | 1 | |
| dosage: | 50 | mg |
| volume of distribution: | 0.6 | L |
| clearance: | 1 | mL/min/kg |
| other parameters in model implementation | ||
Mercuric chloride is an inorganic compound of mercury historically used as a topical antiseptic and disinfectant. Due to its high toxicity and risk of mercury poisoning, it is no longer in clinical use for humans and is primarily used in laboratory research and as a fungicide or preservative in industry.
Pharmacokinetics
No pharmacokinetic parameters in human subjects are available in published literature due to the high toxicity and discontinued therapeutic use of mercuric chloride. Toxicokinetic values are occasionally described in animal studies, but no standardized human PK models exist.
References
Nielsen, JB (1992). Toxicokinetics of mercuric chloride and methylmercuric chloride in mice. Journal of toxicology and environmental health 37(1) 85–122. DOI:10.1080/15287399209531659 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1522616
Sandborgh-Englund, G, et al., & Ekstrand, J (2004). Gastrointestinal absorption of metallic mercury. Archives of environmental health 59(9) 449–454. DOI:10.1080/00039890409603424 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16381485
Tinggi, U, et al., & Seawright, A (2016). Bioavailability study of arsenic and mercury in traditional Chinese medicines (TCM) using an animal model after a single dose exposure. Regulatory toxicology and pharmacology : RTP 76 51–56. DOI:10.1016/j.yrtph.2016.01.010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26804582
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)