modelTestosterone
Extends from Pharmacolibrary.Drugs.ATC.G.G03BA03.
Information
| name: | Testosterone | |
| ATC code: | G03BA03 | route: | intramuscular |
| compartments: | 1 | |
| dosage: | 250 | mg |
| volume of distribution: | 1.0 | L |
| clearance: | 0.7 | L/h/kg |
| other parameters in model implementation | ||
Testosterone is a naturally occurring steroid hormone that plays a key role in the development of male reproductive tissues and secondary sexual characteristics. It is used clinically for testosterone replacement therapy in males with hypogonadism and in certain other endocrine disorders. Testosterone is an approved drug for therapeutic use in many countries.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult males following single intramuscular injection of testosterone enanthate.
References
Pastuszak, AW, et al., & Hu, Y (2021). Population Pharmacokinetic Modeling and Simulations to Evaluate a Potential Dose Regimen of Testosterone Undecanoate in Hypogonadal Males. Journal of clinical pharmacology 61(12) 1618–1625. DOI:10.1002/jcph.1939 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34269421
Vogiatzi, MG, et al., & Rogol, AD (2023). Allometric Scaling of Testosterone Enanthate Pharmacokinetics to Adolescent Hypogonadal Males (IM and SC Administration). Journal of the Endocrine Society 7(6) bvad059–None. DOI:10.1210/jendso/bvad059 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37180212
Chioma, L, & Cappa, M (2023). Hypogonadism in Male Infants and Adolescents: New Androgen Formulations. Hormone research in paediatrics 96(6) 581–589. DOI:10.1159/000521455 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34915486
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)