modelProgesterone
Extends from Pharmacolibrary.Drugs.ATC.G.G03DA04.
Information
| name: | Progesterone | |
| ATC code: | G03DA04 | route: | oral |
| compartments: | 1 | |
| dosage: | 200 | mg |
| volume of distribution: | 20.7 | L |
| clearance: | 5.4 | L/h/kg |
| other parameters in model implementation | ||
Progesterone is a natural steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis. It is used as a medication primarily for hormone replacement therapy, treatment of menstrual disorders, and as a component of hormonal contraceptives. Progesterone is approved for use today in various oral, vaginal, and injectable forms.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult women after a single oral dose administration of micronized progesterone.
References
Wang, H, et al., & Deng, C (2019). Pharmacokinetics of hard micronized progesterone capsules via vaginal or oral route compared with soft micronized capsules in healthy postmenopausal women: a randomized open-label clinical study. Drug design, development and therapy 13 2475–2482. DOI:10.2147/DDDT.S204624 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31440031
Beumer, JH, & Foldi, J (2023). Pharmacology and pharmacokinetics of elacestrant. Cancer chemotherapy and pharmacology 92(2) 157–163. DOI:10.1007/s00280-023-04550-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37314500
Liu, H, et al., & Schultze-Mosgau, MH (2021). Pharmacokinetics and Safety of the Selective Progesterone Receptor Modulator Vilaprisan in Chinese Healthy Postmenopausal Women. Clinical pharmacology in drug development 10(5) 486–493. DOI:10.1002/cpdd.851 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32716091
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)