modelTrospium
Extends from Pharmacolibrary.Drugs.ATC.G.G04BD09.
Information
| name: | Trospium | |
| ATC code: | G04BD09 | route: | oral |
| compartments: | 1 | |
| dosage: | 20 | mg |
| volume of distribution: | 395 | L |
| clearance: | 61 | L/h |
| other parameters in model implementation | ||
Trospium is a quaternary ammonium antimuscarinic agent used in the treatment of overactive bladder with symptoms of urge incontinence, urgency, and urinary frequency. It acts as a muscarinic antagonist that inhibits involuntary contractions of the bladder. Trospium is approved and in current use for these indications.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers (mixed sex, n=24), following a single oral dose under fasting conditions.
References
Doroshyenko, O, et al., & Fuhr, U (2005). Clinical pharmacokinetics of trospium chloride. Clinical pharmacokinetics 44(7) 701–720. DOI:10.2165/00003088-200544070-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15966754
Harnett, MD, et al., & Sandage, BW (2013). Study of the population pharmacokinetic characteristics of once-daily trospium chloride 60 mg extended-release capsules in patients with overactive bladder and in healthy subjects. Clinical drug investigation 33(2) 133–141. DOI:10.1007/s40261-012-0039-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23203138
Ganguly, A, et al., & Tyagi, P (2023). Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options. Drugs & aging 40(3) 241–261. DOI:10.1007/s40266-023-01009-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36879156
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)