modelMethylprednisolone
Extends from Pharmacolibrary.Drugs.ATC.H.H02AB04.
Information
| name: | Methylprednisolone | |
| ATC code: | H02AB04 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 36 | mg |
| volume of distribution: | 38.4 | L |
| clearance: | 10.6 | L/h |
| other parameters in model implementation | ||
Methylprednisolone is a synthetic glucocorticoid corticosteroid drug with potent anti-inflammatory and immunosuppressive properties. It is widely used to treat conditions such as allergic reactions, autoimmune diseases, certain types of arthritis, and is also employed in transplant rejection prophylaxis. It is approved and commonly used in clinical practice today.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers after intravenous bolus injection.
References
Barth, J, et al., & Möllenhoff, G (2004). Population pharmacokinetics of methylprednisolone in accident victims with spinal cord injury. International journal of clinical pharmacology and therapeutics 42(9) 504–511. DOI:10.5414/cpp42504 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15487809
Hornik, CP, et al., & Cohen-Wolkowiez, M (2019). Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass. CPT: pharmacometrics & systems pharmacology 8(12) 913–922. DOI:10.1002/psp4.12470 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31646767
Fokkink, WJR, et al., & Jacobs, BC (2022). Population Pharmacokinetic Modelling of Intravenous Immunoglobulin Treatment in Patients with Guillain-Barré Syndrome. Clinical pharmacokinetics 61(9) 1285–1296. DOI:10.1007/s40262-022-01136-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/35781631
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)