modelBenzathineBenzylpenicill
Extends from Pharmacolibrary.Drugs.ATC.J.J01CE08.
Information
| name: | BenzathineBenzylpenicillin | |
| ATC code: | J01CE08 | route: | intramuscular |
| compartments: | 1 | |
| dosage: | 1200000 | mg |
| volume of distribution: | 0.3 | L |
| clearance: | 0.03 | L/h/kg |
| other parameters in model implementation | ||
Benzathine benzylpenicillin (also known as penicillin G benzathine) is a long-acting depot antibiotic in the penicillin class, primarily used for the treatment and prophylaxis of infections caused by susceptible bacteria, such as group A Streptococcus (including rheumatic fever prophylaxis) and syphilis. It is approved and still used in medicine, typically administered by deep intramuscular injection.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult subjects after single intramuscular dose.
References
Kado, JH, et al., & Manning, L (2020). Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection: a randomized, crossover, population pharmacokinetic study in healthy adult volunteers. The Journal of antimicrobial chemotherapy 75(10) 2951–2959. DOI:10.1093/jac/dkaa282 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32696033
Hand, RM, et al., & Carapetis, J (2019). A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: new insights for improved secondary prophylaxis strategies. The Journal of antimicrobial chemotherapy 74(7) 1984–1991. DOI:10.1093/jac/dkz076 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30989171
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)