modelCloxacillin
Extends from Pharmacolibrary.Drugs.ATC.J.J01CF02.
Information
| name: | Cloxacillin | |
| ATC code: | J01CF02 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 11.7 | L |
| clearance: | 7.12 | L/h |
| other parameters in model implementation | ||
Cloxacillin is a beta-lactam antibiotic of the penicillinase-resistant penicillin class. It is mainly used for the treatment of infections caused by penicillinase-producing staphylococci, particularly skin, respiratory tract, bone, and joint infections. Cloxacillin is approved for clinical use and remains a recommended choice for staphylococcal infections in many guidelines.
Pharmacokinetics
Pharmacokinetic parameters of cloxacillin reported in healthy adult volunteers (mixed sexes).
References
Courjon, J, et al., & Goutelle, S (2020). A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during . Antimicrobial agents and chemotherapy 64(12) –. DOI:10.1128/AAC.01562-20 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32988822
James, ME, et al., & Sasi, P (2024). Gentamicin concentration and acute kidney injury in term neonates treated for neonatal sepsis with gentamicin and ampicillin-cloxacillin combination. Antimicrobial agents and chemotherapy 68(6) e0149523–None. DOI:10.1128/aac.01495-23 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38747600
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)