modelCefadroxil
Extends from Pharmacolibrary.Drugs.ATC.J.J01DB05.
Information
| name: | Cefadroxil | |
| ATC code: | J01DB05 | route: | oral |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 18.0 | L |
| clearance: | 2.08 | L/hr |
| other parameters in model implementation | ||
Cefadroxil is an orally administered first-generation cephalosporin antibiotic approved for the treatment of susceptible bacterial infections, including skin and soft tissue infections, urinary tract infections, and pharyngitis/tonsillitis. It is widely used and remains approved for clinical use in many countries.
Pharmacokinetics
Pharmacokinetic parameters from healthy adult volunteers following single oral dose administration.
References
Haynes, AS, et al., & Fish, DN (2024). Cefadroxil and cephalexin pharmacokinetics and pharmacodynamics in children with musculoskeletal infections. Antimicrobial agents and chemotherapy 68(5) e0018224–None. DOI:10.1128/aac.00182-24 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38597672
Rahim, N, et al., & Khalique, UA (2016). Comparative bioavailability and pharmacokinetic study of Cefadroxil capsules in male healthy volunteers of Pakistan. Pakistan journal of pharmaceutical sciences 29(2) 453–459. PUBMED:https://pubmed.ncbi.nlm.nih.gov/27087092
Craft, JC, & Siepman, N (1993). Overview of the safety profile of clarithromycin suspension in pediatric patients. The Pediatric infectious disease journal 12(12 Suppl 3) S142–S147. DOI:10.1097/00006454-199312003-00009 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8295816
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)