modelColistin
Extends from Pharmacolibrary.Drugs.ATC.J.J01XB01.
Information
| name: | Colistin | |
| ATC code: | J01XB01 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 300 | mg |
| volume of distribution: | 13.6 | L |
| clearance: | 2.98 | L/h |
| other parameters in model implementation | ||
Colistin (polymyxin E) is a polymyxin antibiotic used to treat infections caused by multidrug-resistant Gram-negative bacteria, especially in hospital settings. It is considered a last-resort treatment for serious infections such as pneumonia, bloodstream infections, and urinary tract infections due to resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. As of today, it is approved for clinical use, particularly for severe infections where other antibiotics are ineffective.
Pharmacokinetics
Pharmacokinetic parameters for intravenous colistin administration (as colistimethate sodium) in adult critically ill patients with normal renal function.
References
Xie, YL, et al., & Peng, Y (2022). Population pharmacokinetics of intravenous colistin sulfate and dosage optimization in critically ill patients. Frontiers in pharmacology 13 967412–None. DOI:10.3389/fphar.2022.967412 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36105229
Nation, RL, et al., & Silveira, FP (2017). Dosing guidance for intravenous colistin in critically-ill patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 64(5) 565–571. DOI:10.1093/cid/ciw839 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28011614
Ooi, MH, et al., & Nation, RL (2019). Population Pharmacokinetics of Intravenous Colistin in Pediatric Patients: Implications for the Selection of Dosage Regimens. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 69(11) 1962–1968. DOI:10.1093/cid/ciz067 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30722017
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)