modelAmphotericinB
Extends from Pharmacolibrary.Drugs.ATC.J.J02AA01.
Information
| name: | AmphotericinB | |
| ATC code: | J02AA01 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 50 | mg |
| volume of distribution: | 3.4 | L |
| clearance: | 0.083 | L/h/kg |
| other parameters in model implementation | ||
Amphotericin B is a polyene antifungal medication used primarily for the treatment of life-threatening systemic fungal infections. It acts by binding to ergosterol in fungal cell membranes, causing cell death. It is approved and widely used, particularly for severe infections caused by Candida, Aspergillus, and Cryptococcus species.
Pharmacokinetics
Pharmacokinetic parameters reported for adult patients (both sexes) treated for systemic fungal infections by intravenous administration of amphotericin B deoxycholate.
References
Groll, AH, et al., & Brüggemann, RJM (2019). Clinical Pharmacokinetics, Pharmacodynamics, Safety and Efficacy of Liposomal Amphotericin B. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 68(Suppl 4) S260–S274. DOI:10.1093/cid/ciz076 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31222253
Würthwein, G, et al., & Walsh, TJ (2005). Population pharmacokinetics of amphotericin B lipid complex in neonates. Antimicrobial agents and chemotherapy 49(12) 5092–5098. DOI:10.1128/AAC.49.12.5092-5098.2005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16304177
Nath, CE, et al., & Earl, JW (2001). Population pharmacokinetics of amphotericin B in children with malignant diseases. British journal of clinical pharmacology 52(6) 671–680. DOI:10.1046/j.0306-5251.2001.01496.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/11736878
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)