modelFamciclovir
Extends from Pharmacolibrary.Drugs.ATC.J.J05AB09.
Information
| name: | Famciclovir | |
| ATC code: | J05AB09 | route: | oral |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 62 | L |
| clearance: | 35 | L/h |
| other parameters in model implementation | ||
Famciclovir is an oral prodrug of penciclovir, an antiviral agent used primarily for the treatment of herpes zoster (shingles) and herpes simplex virus infections. It is approved for use in adults and adolescents and is widely used today.
Pharmacokinetics
Pharmacokinetic parameters derived from healthy adult subjects following a single oral dose of famciclovir 500 mg.
References
Schenkel, F, et al., & Daali, Y (2013). Intraocular penetration of penciclovir after oral administration of famciclovir: a population pharmacokinetic model. The Journal of antimicrobial chemotherapy 68(7) 1635–1641. DOI:10.1093/jac/dkt064 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23539240
Ogungbenro, K, et al., & Aarons, L (2009). Population pharmacokinetics and optimal design of paediatric studies for famciclovir. British journal of clinical pharmacology 68(4) 546–560. DOI:10.1111/j.1365-2125.2009.03479.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/19843058
Blumer, J, et al., & Hamed, K (2010). Single-dose pharmacokinetics of famciclovir in infants and population pharmacokinetic analysis in infants and children. Antimicrobial agents and chemotherapy 54(5) 2032–2041. DOI:10.1128/AAC.01508-09 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20160046
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)