modelPneumococcusPurifiedPolysacchari
Extends from Pharmacolibrary.Drugs.ATC.J.J07AL52.
Information
| name: | PneumococcusPurifiedPolysaccharidesAntigenAndHaemophilusInfluenzaeConjugated |
| ATC code: | J07AL52 | route: | intramuscular |
| n-compartments | 1 |
This is a combination vaccine containing purified polysaccharide antigens from Streptococcus pneumoniae (pneumococcus) and Haemophilus influenzae type b conjugated to a carrier protein (such as tetanus toxoid). It is used to induce immunity against invasive diseases caused by these bacteria, such as pneumonia, meningitis, and sepsis in infants and young children. The vaccine is approved and in clinical use for pediatric immunization, particularly in schedules for young children under the age of 5.
Pharmacokinetics
No specific pharmacokinetic parameters (absorption, distribution, metabolism, excretion) are reported for this vaccine in the literature, as vaccines composed of polysaccharide-protein conjugates function primarily by immunogenicity and not classical pharmacokinetics. Most published data focus on immunogenicity and clinical efficacy rather than serum concentrations or elimination rates. Typical study participants are healthy infants or children without underlying immunodeficiency.
References
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 initial generated model