modelPneumococcalVaccinesComb
Extends from Pharmacolibrary.Drugs.ATC.J.J07BC20.
Information
| name: | PneumococcalVaccinesCombinations | |
| ATC code: | J07BC20 | route: | intramuscular |
| compartments: | 1 | |
| dosage: | 0.5 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | l/h |
| other parameters in model implementation | ||
ATC code J07BC20 covers combinations of pneumococcal vaccines. These are used to induce immunity against infections caused by Streptococcus pneumoniae. The vaccines are typically composed of polysaccharide-protein conjugates covering multiple pneumococcal serotypes. They are recommended for infants, children, adults over 65, and individuals at risk for severe pneumococcal disease. Such combination vaccines (e.g., PCV13, PCV15, PCV20) are approved and widely used today for routine immunization.
Pharmacokinetics
Pharmacokinetics of pneumococcal vaccine components such as conjugated polysaccharides are generally not described using standard compartmental PK, since vaccines act through immunogenicity not classic ADME characteristics. No peer-reviewed publications report conventional pharmacokinetic parameters (compartmental, clearance, etc.) for J07BC20 pneumococcal combinations.
References
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)