modelDiphtheriaHaemophilusInf
Extends from Pharmacolibrary.Drugs.ATC.J.J07CA09.
Information
| name: | DiphtheriaHaemophilusInfluenzaeBPertussisPoliomyelitisTetanusHepatitisB | |
| ATC code: | J07CA09 | route: | intramuscular |
| compartments: | 1 | |
| dosage: | 0.5 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | |
| other parameters in model implementation | ||
This combination vaccine provides immunization against diphtheria, Haemophilus influenzae type B, pertussis (whooping cough), poliomyelitis, tetanus, and hepatitis B. It is indicated for the prevention of these infectious diseases in pediatric populations. Such combination vaccines are used globally, primarily in routine childhood vaccination schedules. They are approved and widely used to reduce the number of injections required for immunization.
Pharmacokinetics
No comprehensive pharmacokinetic model parameters for the full diphtheria-haemophilus influenzae B-pertussis-poliomyelitis-tetanus-hepatitis B combination vaccine are reported in the indexed scientific literature, as these are vaccine antigens and not conventional small-molecule drugs. Pharmacokinetics are not generally described for such antigenic vaccines; rather, pharmacodynamics (immunogenicity) is the main focus.
References
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)