modelAntilymphocyteImmunoglobulinHors
Extends from Pharmacolibrary.Drugs.ATC.L.L04AA03.
Information
| name: | AntilymphocyteImmunoglobulinHorse |
| ATC code: | L04AA03 | route: | intravenous |
| n-compartments | 1 |
Antilymphocyte immunoglobulin (horse) is a polyclonal antibody preparation derived from the serum of horses immunized with human lymphocytes. It is primarily used as an immunosuppressive agent in the treatment and prevention of acute rejection in organ transplantation and in the management of aplastic anemia, particularly in patients unsuitable for stem cell transplantation. Its use has declined due to the availability of rabbit-derived preparations with a better safety profile, but it is still used in some regions.
Pharmacokinetics
No population pharmacokinetic studies or human pharmacokinetic parameter publications were identified for antithymocyte/antilymphocyte globulin (horse) in the scientific literature as of 2024. PK characteristics such as clearance or volume of distribution are largely unknown; estimates here are based on general immunoglobulin G pharmacokinetics and available dosing information.
References
McCune, JS, et al., & O'Donnell, PV (2012). A pilot pharmacologic biomarker study of busulfan and fludarabine in hematopoietic cell transplant recipients. Cancer chemotherapy and pharmacology 69(1) 263–272. DOI:10.1007/s00280-011-1736-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21909959
Admiraal, R, et al., & Boelens, JJ (2017). Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a multicentre, retrospective, pharmacodynamic cohort analysis. The Lancet. Haematology 4(4) e183–e191. DOI:10.1016/S2352-3026(17)30029-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28330607
Andersson, BS, et al., & Champlin, RE (2011). Clofarabine ± fludarabine with once daily i.v. busulfan as pretransplant conditioning therapy for advanced myeloid leukemia and MDS. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 17(6) 893–900. DOI:10.1016/j.bbmt.2010.09.022 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20946966
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 initial generated model