modelCisatracurium
Extends from Pharmacolibrary.Drugs.ATC.M.M03AC11.
Information
| name: | Cisatracurium | |
| ATC code: | M03AC11 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 0.15 | mg |
| volume of distribution: | 0.145 | L |
| clearance: | 2.84 | mL/min/kg |
| other parameters in model implementation | ||
Cisatracurium is a non-depolarizing neuromuscular blocking agent used for skeletal muscle relaxation during surgical procedures and mechanical ventilation in intensive care units. It is a benzylisoquinolinium compound and is approved for clinical use today, particularly favored due to organ-independent metabolism (Hofmann elimination), making it suitable for patients with hepatic or renal impairment.
Pharmacokinetics
Typical pharmacokinetics in healthy adult patients after single intravenous bolus dose; parameters largely independent of age and sex due to predominant Hoffman elimination.
References
Kisor, DF, & Schmith, VD (1999). Clinical pharmacokinetics of cisatracurium besilate. Clinical pharmacokinetics 36(1) 27–40. DOI:10.2165/00003088-199936010-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9989341
Dahaba, AA, et al., & Reibnegger, G (2022). Location matters: Overlooked ethnic-geographic effect in China and Austria on propofol/cisatracurium sex differences among a population pharmacokinetic/pharmacodynamic (PopPK/PD) covariate analysis in men, women, and one transgender subject. Fundamental & clinical pharmacology 36(1) 182–198. DOI:10.1111/fcp.12704 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34050969
Muravchick, S (1998). The effects of aging on anesthetic pharmacology. Acta anaesthesiologica Belgica 49(2) 79–84. PUBMED:https://pubmed.ncbi.nlm.nih.gov/9675376
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)