modelSevoflurane
Extends from Pharmacolibrary.Drugs.ATC.N.N01AB08.
Information
| name: | Sevoflurane | |
| ATC code: | N01AB08 | route: | inhalational |
| compartments: | 2 | |
| dosage: | 2 | mg |
| volume of distribution: | 93 | L |
| clearance: | 1.12 | L/min |
| other parameters in model implementation | ||
Sevoflurane is a volatile, non-flammable inhalational anesthetic agent used for the induction and maintenance of general anesthesia in both adults and pediatric patients. It is widely approved and commonly used in clinical anesthesia practice due to its low blood/gas partition coefficient, allowing for rapid induction and recovery.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers, post steady-state inhalational administration.
References
Dholakia, U, et al., & Pypendop, BH (2020). Pharmacokinetics of midazolam in sevoflurane-anesthetized cats. Veterinary anaesthesia and analgesia 47(2) 200–209. DOI:10.1016/j.vaa.2019.11.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31983556
Cortínez, LI, & Anderson, BJ (2018). Modeling the pharmacokinetics and pharmacodynamics of sevoflurane using compartment models in children and adults. Paediatric anaesthesia 28(10) 834–840. DOI:10.1111/pan.13465 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30117213
Enlund, M, et al., & Meineke, I (2008). Population pharmacokinetics of sevoflurane in conjunction with the AnaConDa: toward target-controlled infusion of volatiles into the breathing system. Acta anaesthesiologica Scandinavica 52(4) 553–560. DOI:10.1111/j.1399-6576.2008.01579.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/18339161
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)