modelXenon
Extends from Pharmacolibrary.Drugs.ATC.N.N01AX15.
Information
| name: | Xenon | |
| ATC code: | N01AX15 | route: | inhalational |
| compartments: | 1 | |
| dosage: | 50 | mg |
| volume of distribution: | 1.69 | L |
| clearance: | 15.4 | L/min |
| other parameters in model implementation | ||
Xenon is a noble gas used as an inhalational general anesthetic. It offers minimal hemodynamic and respiratory side effects, negligible metabolism, and neuroprotective potential. Xenon is not widely used clinically today due to high cost and limited availability, but has been studied as an alternative to conventional inhalational anesthetics.
Pharmacokinetics
Pharmacokinetic parameters based on healthy adult volunteers exposed to subanesthetic and anesthetic concentrations of xenon in clinical settings.
References
Castronovo, FP, et al., & Barton, NW (1993). Radiopharmacology of inhaled 133Xe in skeletal sites containing deposits of Gaucher cells. Nuclear medicine and biology 20(5) 707–714. DOI:10.1016/0969-8051(93)90042-s PUBMED:https://pubmed.ncbi.nlm.nih.gov/8358357
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)