modelGabapentin
Extends from Pharmacolibrary.Drugs.ATC.N.N02BF01.
Information
| name: | Gabapentin | |
| ATC code: | N02BF01 | route: | oral |
| compartments: | 1 | |
| dosage: | 300 | mg |
| volume of distribution: | 58 | L |
| clearance: | 6.7 | L/h |
| other parameters in model implementation | ||
Gabapentin is an anticonvulsant medication primarily used to treat neuropathic pain and partial seizures. It is also approved for the management of postherpetic neuralgia and is widely used off-label for various pain syndromes and anxiety disorders. Gabapentin is currently approved and in clinical use in many countries.
Pharmacokinetics
Pharmacokinetic parameters derived from studies in healthy adult volunteers following a single oral dose.
References
Hampton, CE, et al., & Pypendop, BH (2021). Pharmacokinetics of oral and compounded intravenous gabapentin in Duroc swine (Sus Scrofa). Journal of veterinary pharmacology and therapeutics 44(5) 776–782. DOI:10.1111/jvp.12977 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33978255
Adrian, D, et al., & Lascelles, BDX (2018). The pharmacokinetics of gabapentin in cats. Journal of veterinary internal medicine 32(6) 1996–2002. DOI:10.1111/jvim.15313 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30307652
Tran, P, et al., & Lee, YB (2017). Population pharmacokinetics of gabapentin in healthy Korean subjects with influence of genetic polymorphisms of ABCB1. Journal of pharmacokinetics and pharmacodynamics 44(6) 567–579. DOI:10.1007/s10928-017-9549-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29018999
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)