modelMephenytoin
Extends from Pharmacolibrary.Drugs.ATC.N.N03AB04.
Information
| name: | Mephenytoin | |
| ATC code: | N03AB04 | route: | oral |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 0.7 | L |
| clearance: | 40 | mL/min |
| other parameters in model implementation | ||
Mephenytoin is an anticonvulsant medication belonging to the hydantoin class, historically used for the treatment of epilepsy and other seizure disorders. Due to the risk of severe adverse effects such as aplastic anemia, it is not commonly used or approved for clinical practice today.
Pharmacokinetics
Estimated pharmacokinetic parameters for adult healthy individuals, as no robust published PK parameters were found. Estimates are based on known metabolism (hepatic, CYP2C19), structural similarity to phenytoin, and limited historical reports.
References
Sohn, DR, et al., & Chiba, K (1992). Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clinical pharmacology and therapeutics 52(2) 160–169. DOI:10.1038/clpt.1992.125 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1505151
Wedlund, PJ, et al., & Wilkinson, GR (1985). Phenotypic differences in mephenytoin pharmacokinetics in normal subjects. The Journal of pharmacology and experimental therapeutics 234(3) 662–669. PUBMED:https://pubmed.ncbi.nlm.nih.gov/4032286
Balian, JD, et al., & Flockhart, DA (1995). The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study. Clinical pharmacology and therapeutics 57(6) 662–669. DOI:10.1016/0009-9236(95)90229-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7781266
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)