modelEslicarbazepine
Extends from Pharmacolibrary.Drugs.ATC.N.N03AF04.
Information
| name: | Eslicarbazepine | |
| ATC code: | N03AF04 | route: | oral |
| compartments: | 1 | |
| dosage: | 800 | mg |
| volume of distribution: | 61 | L |
| clearance: | 20 | L/h |
| other parameters in model implementation | ||
Eslicarbazepine is an anticonvulsant drug used primarily as adjunctive therapy for partial-onset seizures in adults with epilepsy. It is the active metabolite of eslicarbazepine acetate and acts mainly as a voltage-gated sodium channel blocker. Eslicarbazepine is approved in several countries, including under the trade name Zebinix or Aptiom.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers (mixed sex) after oral administration of eslicarbazepine acetate, reporting data for the active metabolite eslicarbazepine.
References
Gidal, BE, et al., & Sunkaraneni, S (2018). Exposure-safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate. Acta neurologica Scandinavica 138(3) 203–211. DOI:10.1111/ane.12950 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29732549
Jacob, S, & Nair, AB (2016). An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs. Drugs in R&D 16(4) 303–316. DOI:10.1007/s40268-016-0148-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27766590
Sunkaraneni, S, et al., & Fiedler-Kelly, J (2018). Population Pharmacokinetics and Exposure-Response Analyses of Eslicarbazepine Acetate Efficacy and Safety in Monotherapy of Partial-Onset Seizures. Journal of clinical pharmacology 58(7) 927–938. DOI:10.1002/jcph.1086 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29528499
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)