modelLorazepam_1
Extends from Pharmacolibrary.Drugs.ATC.N.N05BA06_1.
Information
| name: | Lorazepam_1 | |
| ATC code: | N05BA06_1 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 2 | mg |
| volume of distribution: | 1.19 | L |
| clearance: | 1.33 | mL/min/kg |
| other parameters in model implementation | ||
Lorazepam is a short-acting benzodiazepine used primarily to treat anxiety disorders, insomnia, status epilepticus, and as premedication for anesthesia. It has anxiolytic, sedative, anticonvulsant, and muscle relaxant properties. Lorazepam is widely approved and still clinically used today.
Pharmacokinetics
Pharmacokinetic parameters derived from healthy adults after intravenous administration.
References
Gonzalez, D, et al., & Capparelli, EV (2017). Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus. Clinical pharmacokinetics 56(8) 941–951. DOI:10.1007/s40262-016-0486-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27943220
Chamberlain, JM, et al., & van den Anker, JN (2012). Pharmacokinetics of intravenous lorazepam in pediatric patients with and without status epilepticus. The Journal of pediatrics 160(4) 667–672.e2. DOI:10.1016/j.jpeds.2011.09.048 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22050870
Swart, EL, et al., & Strack van Schijndel, RM (2004). Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients. British journal of clinical pharmacology 57(2) 135–145. DOI:10.1046/j.1365-2125.2003.01957.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/14748812
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)