modelClobazam
Extends from Pharmacolibrary.Drugs.ATC.N.N05BA09.
Information
| name: | Clobazam | |
| ATC code: | N05BA09 | route: | oral |
| compartments: | 1 | |
| dosage: | 20 | mg |
| volume of distribution: | 1.3 | L |
| clearance: | 1.7 | L/h |
| other parameters in model implementation | ||
Clobazam is a benzodiazepine derivative used primarily as an adjunctive therapy in the treatment of seizures associated with Lennox-Gastaut syndrome and other epileptic disorders. It is also used for short-term relief of severe anxiety. Clobazam is approved and widely used today for epilepsy management.
Pharmacokinetics
Pharmacokinetic parameters in healthy adult volunteers following single oral dose administration.
References
Tolbert, D, & Larsen, F (2019). A Comprehensive Overview of the Clinical Pharmacokinetics of Clobazam. Journal of clinical pharmacology 59(1) 7–19. DOI:10.1002/jcph.1313 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30285275
Tolbert, D, et al., & Ette, EI (2016). Drug-metabolism mechanism: Knowledge-based population pharmacokinetic approach for characterizing clobazam drug-drug interactions. Journal of clinical pharmacology 56(3) 365–374. DOI:10.1002/jcph.603 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26224203
Yano, I (2019). [Clinical Pharmacometrics for Rational Drug Treatment]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 139(10) 1227–1234. DOI:10.1248/yakushi.19-00124 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31582605
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)