modelFluvoxamine
Extends from Pharmacolibrary.Drugs.ATC.N.N06AB08.
Information
| name: | Fluvoxamine | |
| ATC code: | N06AB08 | route: | oral |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 25 | L |
| clearance: | 20.4 | L/h |
| other parameters in model implementation | ||
Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) primarily used to treat major depressive disorder and obsessive-compulsive disorder (OCD). It is approved and commonly used today in various countries for these indications.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers after single oral dose administration.
References
Zang, YN, et al., & Ruan, CJ (2024). Population pharmacokinetics of olanzapine in pediatric patients with psychiatric disorders. Expert opinion on drug metabolism & toxicology 20(8) 827–840. DOI:10.1080/17425255.2024.2380472 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39010781
DeVane, CL, & Gill, HS (1997). Clinical pharmacokinetics of fluvoxamine: applications to dosage regimen design. The Journal of clinical psychiatry 58 Suppl 5 7–14. PUBMED:https://pubmed.ncbi.nlm.nih.gov/9184622
de Leon, J, et al., & Ruan, CJ (2020). Using therapeutic drug monitoring to personalize clozapine dosing in Asians. Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists 12(2) e12384–None. DOI:10.1111/appy.12384 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32119764
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)