modelTianeptine
Extends from Pharmacolibrary.Drugs.ATC.N.N06AX14.
Information
| name: | Tianeptine | |
| ATC code: | N06AX14 | route: | oral |
| compartments: | 1 | |
| dosage: | 12.5 | mg |
| volume of distribution: | 0.8 | L |
| clearance: | 3.0 | L/h |
| other parameters in model implementation | ||
Tianeptine is an atypical antidepressant primarily used for the treatment of major depressive disorder. It has unique pharmacological properties, including enhancement of serotonin uptake, modulation of glutamatergic activity, and neuroprotective effects. Tianeptine is approved for use in several countries in Europe and Asia, though it is not FDA-approved in the United States.
Pharmacokinetics
Pharmacokinetic parameters for healthy adult volunteers following a single oral dose; data primarily from published studies.
References
Grasela, TH, et al., & Jochemsen, R (1993). Development of a population pharmacokinetic database for tianeptine. European journal of clinical pharmacology 45(2) 173–179. DOI:10.1007/BF00315502 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8223841
Royer, RJ, et al., & Kamoun, A (1988). Pharmacokinetic and metabolic parameters of tianeptine in healthy volunteers and in populations with risk factors. Clinical neuropharmacology 11 Suppl 2 S90–S96. PUBMED:https://pubmed.ncbi.nlm.nih.gov/3180120
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)