modelModafinil
Extends from Pharmacolibrary.Drugs.ATC.N.N06BA07.
Information
| name: | Modafinil | |
| ATC code: | N06BA07 | route: | oral |
| compartments: | 1 | |
| dosage: | 200 | mg |
| volume of distribution: | 0.9 | L |
| clearance: | 42 | mL/min |
| other parameters in model implementation | ||
Modafinil is a wakefulness-promoting agent approved for the treatment of narcolepsy, obstructive sleep apnea, and shift work sleep disorder. It has also been used off-label for various cognitive enhancement purposes.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers, both male and female, after single oral administration.
References
Seng, KY, et al., & Lee, LS (2011). Population pharmacokinetics of modafinil and its acid and sulfone metabolites in Chinese males. Therapeutic drug monitoring 33(6) 719–729. DOI:10.1097/FTD.0b013e318237a9e9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22105589
Tao, G, et al., & Chenhui, D (2010). Population pharmacokinetics of modafinil in Chinese Han, Mongolian, Korean, Uygur, and Hui healthy subjects determined by nonlinear mixed-effects modeling. Therapeutic drug monitoring 32(2) 189–193. DOI:10.1097/FTD.0b013e3181cf27d3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20216121
Wu, KH, et al., & Lu, W (2012). Population pharmacokinetics of modafinil acid and estimation of the metabolic conversion of modafinil into modafinil acid in 5 major ethnic groups of China. Acta pharmacologica Sinica 33(11) 1401–1408. DOI:10.1038/aps.2012.124 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23103618
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)