modelScopolamine
Extends from Pharmacolibrary.Drugs.ATC.S.S01FA02.
Information
| name: | Scopolamine | |
| ATC code: | S01FA02 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 0.4 | mg |
| volume of distribution: | 7.0 | L |
| clearance: | 1.02 | L/min |
| other parameters in model implementation | ||
Scopolamine, also known as hyoscine, is a tropane alkaloid anticholinergic drug used primarily for the prevention of motion sickness, postoperative nausea and vomiting, and as a mydriatic and cycloplegic agent in ophthalmology. It is available in various formulations including oral, transdermal, and parenteral administration. Scopolamine is still in clinical use today, mainly for its antiemetic properties and ophthalmological purposes.
Pharmacokinetics
Pharmacokinetic parameters in healthy male adult volunteers after intravenous administration.
References
Alvarez-Jimenez, R, et al., & Stevens, J (2016). Model-based exposure-response analysis to quantify age related differences in the response to scopolamine in healthy subjects. British journal of clinical pharmacology 82(4) 1011–1021. DOI:10.1111/bcp.13031 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27273555
Hudson, RJ, et al., & Peterson, MD (2001). Pharmacokinetics of sufentanil in patients undergoing coronary artery bypass graft surgery. Journal of cardiothoracic and vascular anesthesia 15(6) 693–699. DOI:10.1053/jcan.2001.28311 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11748515
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)