modelFluoresceinCombinations
Extends from Pharmacolibrary.Drugs.ATC.S.S01JA51.
Information
| name: | FluoresceinCombinations | |
| ATC code: | S01JA51 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 500 | mg |
| volume of distribution: | 0.5 | L |
| clearance: | 1.6 | mL/min/kg |
| other parameters in model implementation | ||
Fluorescein is a synthetic organic compound and fluorophore used as a diagnostic agent in ophthalmology for visualizing corneal abrasions, retinal blood flow, and other eye conditions. It is usually administered topically or intravenously. In combinations (ATC S01JA51), it is used for diagnostic purposes in combination with other agents such as local anaesthetics. Fluorescein is an approved drug and widely used in current clinical practice.
Pharmacokinetics
No published pharmacokinetic (PK) data specific for fluorescein, combinations (ATC S01JA51) was found. PK parameters are estimated based on intravenous administration of fluorescein in healthy adults.
References
Thorling, CA, et al., & Roberts, MS (2015). Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition. Drug metabolism and disposition: the biological fate of chemicals 43(1) 154–162. DOI:10.1124/dmd.114.060848 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25380806
Gosain, AK, et al., & Upton, RA (1991). Relationship between skin fluorescence and blood flow in normal and in chronically ischemic subjects dosed with fluorescein. Journal of pharmaceutical sciences 80(7) 632–637. DOI:10.1002/jps.2600800704 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1941558
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)