modelGentamicin
Extends from Pharmacolibrary.Drugs.ATC.S.S02AA14.
Information
| name: | Gentamicin | |
| ATC code: | S02AA14 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 80 | mg |
| volume of distribution: | 0.25 | L |
| clearance: | 3.6 | L/hr |
| other parameters in model implementation | ||
Gentamicin is an aminoglycoside antibiotic active against many Gram-negative and some Gram-positive bacteria. It is mainly used for the treatment of serious infections such as sepsis, respiratory tract infections, urinary tract infections, and endocarditis. Gentamicin is approved and widely used today, especially in hospital settings.
Pharmacokinetics
Pharmacokinetic parameters reported for adult healthy volunteers after intravenous administration.
References
Medellín-Garibay, SE, et al., & Barcia, E (2015). Population pharmacokinetics of gentamicin and dosing optimization for infants. Antimicrobial agents and chemotherapy 59(1) 482–489. DOI:10.1128/AAC.03464-14 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25385111
Boisson, M, et al., & Grégoire, N (2018). Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. The Journal of antimicrobial chemotherapy 73(10) 2830–2837. DOI:10.1093/jac/dky239 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29947799
Lares-Asseff, I, et al., & Lugo Goytia, G (2016). Population Pharmacokinetics of Gentamicin in Mexican Children With Severe Malnutrition. The Pediatric infectious disease journal 35(8) 872–878. DOI:10.1097/INF.0000000000001204 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27420805
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)