modelPK_1C_Lithium2
Extends from Pharmacolibrary.Drugs.ATC.N.N05AN01.
Information
| name: | Lithium | |
| ATC code: | N05AN01 | route: | oral |
| compartments: | 1 | |
| dosage: | 300 | mg |
| volume of distribution: | 0.7 | L |
| clearance: | 20 | mL/min |
| other parameters in model implementation | ||
Lithium is a mood stabilizer primarily used in the treatment and prophylaxis of bipolar disorder and, to a lesser extent, depression. It is an approved drug with established efficacy for the prevention of manic and depressive episodes in bipolar disorder. Lithium is also sometimes used off-label for other psychiatric conditions.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adults after oral administration of lithium carbonate.
References
Yuan, J, et al., & Zhu, C (2021). Population Pharmacokinetics of Lithium in Young Pediatric Patients With Intellectual Disability. Frontiers in pharmacology 12 650298–None. DOI:10.3389/fphar.2021.650298 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33935755
Yamaguchi, D, et al., & Kamimura, H (2019). Population Pharmacokinetics and Exposure-Response of Lithium Carbonate in Patients Based on Tubular Reabsorption Mechanisms. European journal of drug metabolism and pharmacokinetics 44(3) 329–338. DOI:10.1007/s13318-018-0536-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30536114
Findling, RL, et al., & Jusko, WJ (2010). First-dose pharmacokinetics of lithium carbonate in children and adolescents. Journal of clinical psychopharmacology 30(4) 404–410. DOI:10.1097/JCP.0b013e3181e66a62 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20531219
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)