packagePharmacokinetic

domain	potential variables	flow variables	stream variables	connector definition	icons
chemical concentration	mass concentration	mass flow rate		Pharmacolibrary.Interfaces  ConcentrationPort, ConcentrationPort_a, ConcentrationPort_b

For administration use one of the variants from package Pharmacolibrary.Sources and specify parameters like F (bioavailability) adminMass adminDuration ...

Use _enteral variant if the drug is not administered directly to blood plasma and goes e.g. via enteral way (oral absorption). 

For distribution compartment use the basic component: NoPerfusedTissueCompartment and specify parameter Vd (volume of distribution)

If more compartments are in models, they need to be connected via intracompartmental clearance using component TransferFirstOrderNonSym and specify parameters CLa and CLb (intracompartmental clearance from A->B and from B->A

For elimination use the component ClearanceDrivenElimination which is the way eliminated by majority of drugs or compounds and specify the parameter CL (clearance rate).

For other specific use cases see the component documentation.

Use the following connector and components that takes into account blood flow.

volumetric flow

pressure

volume flow rate

mass concentration

Pharmacolibrary.Interfaces  FlowPort, FlowPort_a, FlowPort_b

See component documentation and/or examples for further information.

Majority of drug and compounds can be modeled using 1-compartment, 2-compartment, 3-compartment or PBPK model. E.g. you may inherit generic model from Pharmacokinetics.Models.PK_1C and set drug specific parameters.