modelGenericTissueCompartment

Extends from Pharmacolibrary.Interfaces.PartialBloodTissueCompartment, Pharmacolibrary.Interfaces.PartialFlowThrough.

Information

This GenerictTissue compartments is basic component to combine no-perfused tissue compartment with blood plasma flow that might be used to mimic circulation. This component is basic for physiologically based pharmacokinetic (PBPK) model. It defines the equation for mass of drug in this compartment as:

der(M) = qv_a * actualStream(c_a) + qv_b * actualStream(c_b)+q_m

and

c_a=c_b

Variables

M - drug total mass

Parameters

inherited from PartialTissueCompartment

V - total distribution volume

C0 - drug initial concentration in tissue

Parameters

Type	Name	Default	Description
Types.Volume	V (from PartialBloodTissueCompartment)	0.001	total distribution volume
Types.MassConcentration	C0 (from PartialBloodTissueCompartment)	0	drug initial concentration in tissue
Modelica.Units.SI.DimensionlessRatio	kTB (from PartialBloodTissueCompartment)	1	tissue-blood concentration ratio
Modelica.Units.SI.DimensionlessRatio	fu (from PartialBloodTissueCompartment)	1	fraction unbound

Connectors

Type	Name	Default	Description
ConcentrationPort_a	cport (from InterfaceCompartment)
Pharmacolibrary.Interfaces.FlowPort_a	port_a (from PartialTwoPort)
Pharmacolibrary.Interfaces.FlowPort_b	port_b (from PartialTwoPort)

Components

Type	Name	Description
Types.MassConcentration	C (from PartialBloodTissueCompartment)	drug actual concentration in tissue
Types.MassConcentration	CB (from PartialBloodTissueCompartment)	drug concentration in blood or plasma
Types.MassConcentration	freeTissueConc (from PartialBloodTissueCompartment)	drug free concentration in tissue
Types.MassConcentration	freeBloodConc (from PartialBloodTissueCompartment)	drug free concentration in blood or plasma
Types.Mass	M (from PartialBloodTissueCompartment)	drug mass total
Types.AreaUnderCurve	AUC (from PartialBloodTissueCompartment)	area under curve