modelPBPK_whole_body

Diagram of PBPK_whole_body

Extends from Icons.BodyArtieralVenous.

Parameters

TypeNameDefaultDescription
Modelica.Units.SI.MassBW70body weight
Modelica.Units.SI.Densityro985average body density
Types.VolumeFlowRateCO8.333333333333333e-5cardiac output
Tissue Volumes
RealFVad0.213adipose fractional tissue volume
RealFVbo0.085629bone fractional tissue volume
RealFVbr0.02brain fractional tissue volume
RealFVgu0.0171gut fractional tissue volume
RealFVhe0.0047heart fractional tissue volume
RealFVki0.0044kidney fractional tissue volume
RealFVna0.01nasal mucosa fractional tissue volume
RealFVli0.021liver fractional tissue volume
RealFVlu0.0076lung fractional tissue volume
RealFVmu0.4muscle fractional tissue volume
RealFVsk0.0371skin fractional tissue volume
RealFVsp0.0026spleen fractional tissue volume
RealFVte0.01testes fractional tissue volume
RealFVve0.0514venous fractional tissue volume
RealFVar0.0257arterial fractional tissue volume
RealFVpl0.0424plasma fractional tissue volume
RealFVrb0.0347erythrocytes fractional tissue volume
RealFVre0.099771rest of body fractional tissue volume
Tissue Blood Flows
RealFQad0.05adipose fractional blood flow
RealFQbo0.05bone fractional blood flow
RealFQbr0.12brain fractional blood flow
RealFQgu0.146462gut fractional blood flow
RealFQhe0.04heart fractional blood flow
RealFQki0.19kidney fractional blood flow
RealFQna0.01nasal mucosa fractional blood flow
RealFQh0.215385hepatic (venous side) fractional blood flow
RealFQlu1lung fractional blood flow
RealFQmu0.17muscle fractional blood flow
RealFQsk0.05skin fractional blood flow
RealFQsp0.017231spleen fractional blood flow
RealFQte0.01076testes fractional blood flow
RealFQre0.103855rest of body fractional blood flow
Concentration Ratios
RealkTBlu0.8lungs tissue to blood concentration ratio
RealkTBad0.2adipose tissue to blood concentration ratio
RealkTBbo0.25bone tissue to blood concentration ratio
RealkTBbr0.7brain tissue to blood concentration ratio
RealkTBhe0.9heart tissue to blood concentration ratio
RealkTBmu0.85muscle tissue to blood concentration ratio
RealkTBsk0.7skin tissue to blood concentration ratio
RealkTBgu0.9gut tissue to blood concentration ratio
RealkTBli1.35liver tissue to blood concentration ratio
RealkTBsp0.9spleen tissue to blood concentration ratio
RealkTBki1.35kidney tissue to blood concentration ratio
RealkTBna0.7nasal mucosa tissue to blood concentration ratio
RealkTBte0.7testes tissue to blood concentration ratio
RealkTBre0.8rest of body tissue to blood concentration ratio
Other
Types.TransferRatekgit2.776666666666667e-4transfer coeficient from GIT

Connectors

TypeNameDefaultDescription
Interfaces.ConcentrationPort_aarterialDose
Interfaces.ConcentrationPort_avenousDose
Interfaces.ConcentrationPort_aoralDose
Interfaces.ConcentrationPort_ainhalationDose

Components

TypeNameDefaultDescription
Pharmacokinetic.SystemicCompartmentvenous
Pharmacokinetic.FlowGroundflowGround
Pharmacokinetic.TissueCompartmentlungs
Pharmacokinetic.SystemicCompartmentarterial
Pharmacokinetic.FixedFlowadiposeFlow
Pharmacokinetic.TissueCompartmentadipose
Pharmacokinetic.FixedFlowboneFlow
Pharmacokinetic.TissueCompartmentbone
Pharmacokinetic.FixedFlowbrainFlow
Pharmacokinetic.TissueCompartmentbrain
Pharmacokinetic.FixedFlowheartFlow
Pharmacokinetic.TissueCompartmentheart
Pharmacokinetic.TissueCompartmentmuscle
Pharmacokinetic.FixedFlowmuscleFlow
Pharmacokinetic.TissueCompartmentskin
Pharmacokinetic.FixedFlowskinFlow
Pharmacokinetic.TissueCompartmentgut
Pharmacokinetic.TissueCompartmentspleen
Pharmacokinetic.TissueCompartmentliver
Pharmacokinetic.FixedFlowgutFlow
Pharmacokinetic.FixedFlowliverFlow
Pharmacokinetic.FixedFlowspleenFlow
Pharmacokinetic.FixedFlowkidneyFlow
Pharmacokinetic.TissueCompartmentkidney
Pharmacokinetic.ClearanceDrivenEliminationkidneyElim
Pharmacokinetic.ClearanceDrivenEliminationliverElim
TissueCompartmentgonads
FixedFlowtestesFlow
TissueCompartmentrest
FixedFlowrestFlow
UnidirectionalTransportunidirectionalTransport
LumenCompartmentlumenCompartment
Sources.PeriodicDose_EnteralperiodicOralDose
Pharmacolibrary.Sources.PeriodicDose_EnteralperiodicIMDose
Sources.PeriodicDoseperiodicIVDose
Sources.PeriodicDoseperiodicIADose
Pharmacolibrary.Pharmacokinetic.TissueCompartmentnasal_mucosa
Pharmacolibrary.Pharmacokinetic.FixedFlowadiposeFlow1
Pharmacolibrary.Sources.PeriodicDose_EnteralperiodicNasalDose